Chang Liu Lab

1. Lin Yan^#, Litao Wu^#, Xin Chen, Xiaojuan Su,Yuantao Li*,Chang Liu*. Diruetic hormone 31 regulates sleep and memory via distinct signaling pathways in Drosophila melanogaster. Neuroscience Bulletin, 2025, doi.org/10.1007/s12264-025-01476-3
2. Jiayue Gao, Tao Luo*, Chang Liu*. Insight of molecular and neural mechanisms of general anesthesia from invertebrate animal model. Zoological Research, 2025, 46(4):792-810. doi: 10.24272/j.issn.2095-8137.2025.021
3. Lin Yan, Litao Wu, Timothy D. Wiggin, Xiaojuan Su, Wei Yan, Hailiang Li, Lei Li, Zhonghua Lu, Yuantao Li, Zhiqiang Meng, Fang Guo, Fan Li*, Leslie C. Griffith*, Chang Liu*. Brief disruption of activity in a subset of dopaminergic neurons during consolidation impairs long-term memory by fragmenting sleep. eLife, 2025, 14: RP104862. doi: 10.7554/eLife.104862.1
4. Dengyun Ge^#, Chuanliang Han^#, Chang Liu*, Zhiqiang Meng*. Neural oscillations in the somatosensory and motor cortex distinguish dexmedetomidine-induced anesthesia and sleep in rats. CNS Neuroscience & Therapeutics, 2025.31(2):e70262. doi: 10.1111/cns.70262
5. Shiping Zhang, Linfang Wang, Shuanglong Yi, Yu-ting Tsai, Yi-Hsuan Cheng, Yu-Tung Lin, Chia-Ching Lin, YI-Hua Lee, Honglei Wang, Shuhua Li, Ruiqi Wang, Yang Liu, Wei Yan, Chang Liu, Kai-Wen He, Margaret S Ho*. Drosophila aux orchestrates the phosphorylation-dependent assembly of the lysosomal V-ATPase in glia and contributes to SNCA/α-synuclein degradation. Autophagy, 2025 Jan 29: 1-20. doi: 10.1080/15548627.2024.2442858 
6. Wei Yan^#, Zijie Li^#, Ziyi Lin, Shuqin Ji, William Ka Fai Tse, Zhiqiang Meng, Chang Liu*, Lei Li*. Microplastics exposure disturbed sleep structure, reduces the lifespan and ovary size of Drosophila melanogaster. Zoological Research, 2024, 45(4):805-820 (cover paper)
7. Litao Wu, Chang Liu*. Integrated neural circuits of sleep and memory regulation in Drosophila. Current Opinion in Insect Science, 2023, 59:101105. https://doi.org/10.1016/j.cois.2023.101105
8. Bo Chen, Chenyu Jiang, Xiaojuan Su, Chang Liu, Zhiqiang Meng, Yingjie Zhu*. The effect of pulsed electromagnetic field on the locomotor activity and neurotransmitters concentration in different brain regions of mice [J]. Journal of Integration Technology, 2023, 12(2):1-9.
9. Hualong Wang^#, Guiqin Chen^#, Eun Hee Ahn, Yiyuan Xia, Seong Su Kang, Xia Liu, Chang Liu, Ming-Hu Han, Shengdi Chen*, Keqiang Ye*. C/EBPβ/AEP is age-dependently activated in Parkinson’s disease and mediates α-Synuclein in the gut and brain. npj Parkinson's Disease, 2023, 9(1):1; https://doi.org/10.1038/s41531-022-00430-8.
10. Wei Yan, Hai Lin, Junwei Yu, Timothy D. Wiggin, Litao Wu, Zhiqiang Meng, Chang Liu*, Leslie C. Griffith*. Subtype-specific roles of ellipsoid body ring neurons in sleep regulation in Drosophila .  Journal of Neuroscience, 2023, 43(5):764–786 (cover paper)
11. Zhiqiang Meng*, Qing Li, Yuanye Ma, Chang Liu*. Transcranial current stimulation of the frontal-parietal-temporal brain areas reduces cigarette consumption in abstinent heroin users. Journal of Psychiatric Research, 2022, 152:321-325. doi: 10.1016/j.jpsychires.2022.06.045.
12. Qing Li, Yu Fu, Chang Liu*, Zhiqiang Meng*. Transcranial direct current stimulation of the dorsolateral prefrontal cortex for treatment of neuropsychiatric disorders. Frontiers in Behavioral Neuroscience, 2022, 16:893955
13. Wei Yan, Zhiqiang Meng*, Chang Liu*. Selective memory consolidation of the binary compound in feature discrimination tasks in Apis mellifera. Progress in Biochemistry and Biophysics, 2022, 49(7):1358-1368
14. Xi Jin, Yao Tian, Zi Chao Zhang, Pengyu Gu, Chang Liu, Junhai Han*. A subset of DN1p neurons integrates thermosensory inputs to promote wakefulness via CNMa signaling. Current Biology, 2021, 24;31(10):2075-2087.e6.
15. Timothy D. Wiggin, Patricia R. Goodwin, Nathan C. Donelson, Chang Liu, Kien Trinh, Subhabrata Sanyal, Leslie C. Griffith*. Covert sleep-related biological processes are revealed by probabilistic analysis in Drosophila. PNAS, 2020, 117(18)10024-10034
16. Chang Liu*, Zhiqiang Meng^#, Timothy D. Wiggin^#, Junwei Yu, Fang Guo, Martha Reed, Yunpeng Zhang, Michael Rosbash, Leslie C. Griffith*. A serotonin-modulated circuit controls sleep architecture to regulate cognitive function independent of total sleep in Drosophila. Current Biology, 2019, 29(21):3635-3646.
17. Peter Bronk, Elena A. Kuklin, Srinivas Corur-Shandilya, Chang Liu, Timothy D. Wiggin, Martha L. Reed, Eve Marder, Leslie C. Griffith*. Regulation of Eag by calcium/calmodulin controls presynaptic excitability in Drosophila.Journal of Neurophysiology. 2018;119(5):1665-1680.
18. Chang Liu, Paula R. Haynes, Nathan C. Donelson, Shani Aharon, Leslie C. Griffith*. Sleep in populations of Drosophila melanogaster. eNeuro, 2015, 2 (4) e0071-15.2015
19. Zhiqiang Meng*, Chang Liu, Chengyang Yu, Yuanye Ma*. Transcranial direct current stimulation of the frontal-pariental-temporal area attenuates smoking behavior. Journal of Psychiatric Research, 2014 Jul; 54:19-25
20. Chang Liu, Pierre-Yves Plaçais, Nobuhiro Yamagata, Barret D. Pfeiffer, Yoshinori Aso,Anja B.  Friedrich, Igor Siwanowicz, Gerald M. Rubin, Thomas Préat, Hiromu Tanimoto*. A subset of dopamine neurons signals reward for odour memory in Drosophila. Nature, 2012, 488(7412):512-6
21. Yu Mao, Shangchuan Yang, Chang Liu, Xintian Hu*. Effects of propranolol on acquisition and retrieval of morphine-induced conditioned place preference memories in ICR mice. Zoology Research. 2011, 32(6):670-4
22. Zhiqiang Meng, Chang Liu, Xintian Hu*, Yuanye Ma*. Irregular morphine administration affects the retention but not acquisition of conditioned place preference in rats. Brain Research, 2010, 1311: 86-92
23. Zhiqiang Meng^#, Chang Liu^#, Xintian Hu*, Yuanye Ma*. Somatosensory cortices are required for morphine-induced conditioned place preference in rats. PLoS ONE, 2009, 4(11):e7742 (^#co-first author)